Erectile Dysfunction


Future Erectile Dysfunction Treatments

There are a number of new medications and treatments that are being researched or hypothesised, to treat erectile dysfunction. Although we do not offer these treatments, given that they are still in an experimental level, we are nonetheless following closely the developments and we discuss these treatments with patients to the best of our doctors knowledge.

Non PDE5-I oral agents

Newer pharmacological treatments are focused on targeting alternative pathways in the erectile process, both centrally and peripherally. Drug categories currently being investigated for ED include the following:

  • Dopaminergic agents

  • Melanocortin receptor agonists

  • Soluble guanylate cyclase stimulators and activators

  • Rho-kinase inhibitors

Stem cell transplant

Stem cell therapy is a new treatment option that offers the potential to reverse the underlying causes of ED and reduce patient reliance on the transitory effects of PDE5-I medications. It has been researched in several animal studies in subjects who poorly respond to PDE5-Is (cavernous nerve injury and DM). Stem cell regenerative therapy is based on the rationale that stem cells can differentiate into a wide variety of cells including endothelial cells, Schwann cells, smooth muscle cells, and neurons. Moreover, it is hypothesized that stem cells have beneficial effects on damaged or diseased tissues by releasing various molecular mediators, which lead the host tissue to initiate a regenerative or healing response to diseased or injured tissue responsible for ED.

The majority of published studies are based on animal tests but there has been one reported case series of seven men from Korea. In this study, all diabetic patients, with ages ranging from 57 to 87, were treated with an intracavernosal injection of umbilical cord blood stem cells. Morning erection was regained in six out of the seven men at 6 months from time of injection. With concomitant use of sildenafil, all of these men were able to obtain vaginal penetration. No adverse events were reported.

A more recent study reported on a phase I/II clinical trial of intracavernosal injection of stem cells in patients with post-prostatectomy erectile dysfunction. In the authors’ sample size of 12 patients, they used escalating doses of stem cells and no serious side effects were noted. At 6 months, significant improvements of intercourse satisfaction and erectile function were noted in these patients. These results were preliminary and need to be confirmed in phase II trials.

Stem cell transplant therapy is a new frontier in medicine. Larger controlled studies are needed to show any potential benefit at the human level, and further investigation is paramount.

Gene therapy

Gene therapy is a potential therapeutic option that is another area of investigation for the treatment of ED. Genetic material can be easily injected into the penis, which is advantageous as this direct injection avoids potential systemic complications.

In the first human trial, patients were administered a single-dose cavernosal injection of hMaxi-K, a ‘naked’ DNA plasmid carrying the human cDNA encoding the gene for the alpha subunit of the human smooth muscle Maxi-K channel. No adverse events were noted in the 11 patients who received this therapy. Patients given the two highest doses of hMaxi-K had apparent sustained improvements in erectile function as indicated by improved IIEF domain scores over the length of the study.

This was a small study, but the encouraging safety profiles and effectiveness provide evidence that gene therapy is a viable option for the future. The role of stem cell regenerative therapy, in conjunction with gene therapy, will be heavily researched for the treatment of ED in the coming years.

I am suffering from erectile dysfunction, what should I do next?

We advise you to book a consultation with one of our highly experienced doctors. The first step towards successful treatment is an accurate diagnosis of potential causes by our specialists.

After this, our doctors will seek to do two things:

  • design a treatment plan that will allow you immediately to achieve a strong erection to continue normal sexual activities
  • design a treatment plan to address the underlying causes of your erectile dysfunction. This means that each treatment we offer in our clinic is highly personalised.

While our doctor’s experience from over 30,000 erectile dysfunction patients allows us to create detailed treatment plans, a majority of doctors limit treatment options to medication, often leaving the underlying causes untreated. This can lead to a life-long dependence on drugs and in many cases, long term, unsuccessful treatment and your dissatisfaction.



Erectile dysfunction, often referred to as ED, is the inability to achieve and sustain an erection suitable for sexual intercourse. The prevalence of erectile dysfunction increases with age and whilst around 20% of adult men suffer from erectile dysfunction that increases to 50% for men aged 40 and above. Continue Reading....
In order for men to achieve an erection, a number of things need to be functioning correctly Continue Reading....
Obtaining an accurate detailed history for the erectile dysfunction patient is essential in order to make an accurate diagnosis before planning treatment procedures. The initial step is a self-administered patient history questionnaire. Continue Reading....
With the proliferation of oral medications such as Viagra and other PDE-5 inhibitors, the public awareness and treatment options for erectile dysfunction have increased significantly. Continue Reading....
Our ED treatment protocols are based on the latest medical research, medical guidelines and our extensive clinical experience and we expect that 100% of our patients will be able to restore their erectile function. Continue Reading....
There are three main oral drugs categories for erectile dysfunction treatment: vardenafil (Levitra and Staxyn), sildenafil (Viagra) and tadalafil (Cialis) as well as their generic versions. Continue Reading....
The first successful pharmacological treatment of erectile dysfunction was through penile injections of papaverine and phenoxybenzamine. Continue Reading....
Shockwave therapy is the latest treatment option for patients suffering from erectile dysfunction. It is one of the few treatments options that improves natural erections as well as rejuvenating the erection mechanism. Continue Reading....
While there are many therapy based treatments for erectile dysfunction, some patients do not respond to pharmacological therapy such as Cialis or Viagra and surgical treatment provides the only option. Continue Reading....
There are a number of new medications and treatments that are being researched or hypothesised, to treat erectile dysfunction. Continue Reading....
Erectile dysfunction is a multi-factorial disease and in most cases it is a symptom of another disturbance. Every patient treated in our clinic will undergo our extensive diagnostic treatment protocol consisting of the following steps Continue Reading....
Unfortunately, most insurance companies do not cover sexual dysfunction or male fertility consultations and most of our patients are self-financing. Continue Reading....