Peyronie's Disease


Review of the conservative treatment options for Peyronie’s disease

Unfortunately, at this time, no conservative treatment has been comprehensively developed and tested that is as effective in dissolving plaque as the the natural healing mechanism is.

Our doctors have carried out extensive research on the efficacy of different conservative treatments. The main conclusions of this research is summarised below. If you have any questions or concerns about these treatments then we are more than happy to answer these. We do advise patients, considering following any of these treatments, to do so under appropriate medical supervision and never self-administered. Some of these treatments may have side-effects and objective medical monitoring is necessary to identify potential benefits.

Oral medication for Peyronie’s disease

A number of oral drugs and supplements have been proposed and discussed to treat Peyronie’s disease. Unfortunately none of these have displayed significant therapeutic benefits in comparison with placebo research studies. Some have shown some promise and given the minimal side-effects reported, these can be taken by patients. Below we present the most common oral treatments and our assessment of these options:

Vitamin E and propionyl-L-carnitine in isolation and combination

The efficacy of Vitamin E and propionyl-L-carnitine supplements in isolation and combination has proven to be no better than a placebo. We do consider this treatment option as ineffective.

Prescription Drugs


Colchicine is an antigout agent that inhibits scarring however studies suggest that it has no significant effect on Peyronie’s disease.

Potassium aminobenzoate – Potaba

Potaba has shown some limited promise in inhibiting the development of plaques. However it is also associated with severe gastrointestinal side effects and it is relatively expensive and as such we do not recommend it as a treatment option.

Tamoxifen citrate

This is another compound that potentially inhibits scarring but studies have not confirmed this theory yet so its administration is not currently recommended for Peyronie’s disease.


Twice daily administration of 400mg of Pentoxifylline has shown to benefit some patients, resulting in a moderate reduction in plaque size and curvature. The cost of the medication is relatively low and although there are some potential side effects, it is one of the treatments that patients can experiment with during the acute phase of Peyronie’s.


Coenzyme Q10

Daily intake of 300mg of Coenzyme Q10 has shown to result in a moderate decrease in plaque size and curvature as well as inhibiting disease progression. Although further research is required, the results to date are quite encouraging and given the low cost and minimal side-effects, we recommend coenzyme Q10 as a potential conservative treatment option during the acute phase of the condition.


Similarly to Coenzyme Q10, initial studies have shown improvements in pain and curvature from daily intake of Acetyl-L-carnitine. Again further investigation is necessary but given the limited side-effects and low costs, we recommend its use as it might help some patients at this particular stage of Peyronie’s disease.


For patients suffering from a combination of erectile dysfunction and Peyronie’s, daily administration of Cialis 5mg is recommended. This is not only to help patients achieve erections for intercourse (which may not be possible due to curvature) but also non-coital erections can be beneficial with respecting to preventing further deterioration in erectile function (due to increased blood flow) and curvature (if accompanied by mechanical modelling)

Non-steroidal anti-inflammatory medications

These are over the counter medications such as Ibuprofen which can help with the management of pain during the acute phase.

Topical treatments for Peyronie’s Disease

Extracorporeal Shock Wave Lithotripsy (ESWL) for Peyronie’s Disease

There has been extensive research into whether ESWL can have beneficial effects for patients with Peyronie’s disease in a similar way that it has for patients suffering from erectile dysfunction. We were one of the first clinical groups to adopt this new technology for Peyronie’s and unfortunately the results have been disappointing. In particular plaque size and curvature were completely although in some patients, a reduction in pain has been recorded. As such we do not consider ESWL as an effective treatment option for Peyronie’s disease given the associated cost involved.

Transdermal Verapamil Gel

Transdermal Verapamil Gel is a prescription compounded medication that is applied directly to the skin twice a day. There are some studies indicating moderate effectiveness in slowing down the progress of Peyronie’s symptoms but the body of evidence to support this so far is limited. For this reason we do not consider it an effective treatment option.

Other topical treatments

Alternate treatments have been proposed such as applying heat to the plaques. However, there is currently no proven scientific study or insufficient evidence to support any other topical treatments at this point. We are at the leading point in research into this condition and our infield experts are exploring all new innovations and treatment options for our patients.

I am suffering from a what I suspect is Peyronies disease, what should I do next?

If you believe you are suffering from Peyronies and it causes you significant concern we advise you to see a specialist urologist/andrologist.

Our doctors have vast experience treating Peyronies and our clinic is an international referral centre for patients suffering from this condition. We would be happy to review your case and treat you in our clinic.



Peyronie’s, also know as Induratio Penis Plastica, is a disease that leads to the formation of scar tissue plaque on a man’s penis. It affects around 9% of male population and can appear at any age, although the prevalence is higher in men older than 35 years of age. Continue Reading....
We understand that a diagnosis of Peyronie’s is stressful for men. One thing that should always be remembered is that irrespective of the stage and severity of the disease there is always a treatment option as long as patients seek help from specialised doctors. Continue Reading....
Peyronies disease is a progressive disease that develops in two distinct phases. From the onset and for about 12 months, Peyronie’s disease is in the so called Acute Phase, during which the size and morphology of the plaque continue to develop. Continue Reading....
There are various treatment options that have been developed for Peyronie’s disease – these fall under four broad categories for more information, please refer to the dedicated webpages of each treatment option. Continue Reading....
Our Peyronie’s disease treatment procedure is based on the latest medical research, medical guidelines and our extensive clinical experience and with our treatment options, you may be able to avoid surgery. Continue Reading....
Unfortunately, at this time, no conservative treatment has been comprehensively developed and tested that is as effective in dissolving plaque as the the natural healing mechanism is. Continue Reading....
Many patients when they first get diagnosed with Peyronie’s disease try some kind of penile stretching or modelling (during an erection, trying to straighten the penis). Continue Reading....
Based on current scientific evidence, Xiapex is the only non-surgical treatment that has been proved to have a significant impact on the peyronie’s plaque and on average leads to a 35% reduction in penile curvature – however, the results vary significantly from patient to patient with some experiencing even greater improvements. Continue Reading....
The first step for a successful treatment is to select the operating technique that is best suited to your situation. At International Andrology, our expertise in Peyronie’s surgical correction allows us to offer a range of surgical options and we advise our patients as to the treatment that will ensure the best possible result. Continue Reading....
In general, we do not believe there are best techniques but rather the best surgeons. All the techniques we employ have been significantly developed by our surgeons leading to high success rates and patient satisfaction, irrespective of the technique employed. Continue Reading....
The first and most common surgical procedure developed for penis curvature correction is the plication technique. Continue Reading....
Plication surgery involves operating on the healthy, longer side of the penis to make it shorter, while grafting techniques is based on the exact opposite principle; the surgeon operates on the Peyronie’s penile plaque(s) so as to restore lost elasticity (created by plaque) on the affected side of the penis. During an erection, both sides will stretch to the same size, hence eliminating the curvature. Continue Reading....
Around 30% of patients suffering from Peyronie’s disease will also suffer from severe erectile dysfunction. Continue Reading....
Unfortunately, most insurance companies do not cover sexual dysfunction or male fertility consultations and most of our patients are self-paying. If your insurance company covers the cost of treatment or diagnostic tests, then we would be glad to assist you with the refund claim or claim directly from your insurance company on your behalf. Continue Reading....